Comparative Study of Oxidative Stress and Some Enzymatic Parameters in All serotypes of FMD Infected Calves in Thi-Qar Province

Abstract

Abstract
Foot-and-mouth disease is a contagious disease that impacts up to 70 species of cleft hoofed mammals. There are 7
different serotypes of FMDV, O, A, C, Asia1, SAT1, SAT2 and SAT3. Antioxidant mechanisms in mammalian bodies
eliminate reactive oxygen species (ROS), that produces free radicals during stress factors such as viral diseases. Liver
enzymes are highly affected by liver dysfunction that caused by viral infection. This study aimed to detect the effects of
infection with FMD virus on antioxidant status and liver enzymes. This study applied on 80 calves (cow) from different
regions, ages and sexes of Thi-Qar province during the period of December (2024) to March (2025). Blood samples were
gained from 60 affected calves with (FMD virus) as well as other 20 samples from healthy calves -as control. Sera was
classified after detecting the serotypes by Conventional PCR technique. Results reviled that SOD levels in groups A, O
serotypes were significantly reduced when compared with those of mixed group (A&O), (MDA) levels were highly and
significant rise in all afflicted categories compared to the healthy group. also a significant elevation in (ALT) and (AST)
levels in groups of calves of serotype O. G.G.T levels were significantly increased in animals affected with serotype A as
compared with others groups including control. In conclusion FMDV pathogenesis causes oxidative stress, with single
serotypes (A/O) causing more severe antioxidant suppression and profound hepatocellular damage linked to serotype O
infections.